Unani Medicine offers a number of drugs of plant origin to strengthen and enhance the body’s immune system. Having a strong immunity has always been considered important to stay healthy, but it has become even more important in the present scenario, when the whole world is dealing with highly contagious new strains of Corona virus. Strong immunity is the body’s first line of defence which protects it from disease causing virus, bacteria and germs. Unani Medicines play a vital role and hold great importance to improve body’s immune health. Present study deals with the scientific evaluation of some immunity booster Unani Medicinal plants (Berg-e-Rehan, Zanjabeel, Fifil Siyah, Gilo and Haldi) for their pharmacognostical characters, physico-chemical parameters such as ash values, extractives values, thin layer chromatography (TLC), HPTLC, heavy metal estimation, aflatoxin and microbial contamination.